Oral-B Pro-Expert Advance Science is a product developed in collaboration with dental professionals. Its clinically proven effectiveness helps prevent oral problems before they occur and protects teeth and gums from plaque. Oral-B Pro-Expert Advance Science Toothpaste – How Does It Work?Prevents plaque build-up for 24 hours when brushed twice a day.Double-strength cleaning action thanks to a stannous fluoride complex and a plaque-fighting mineral.Inhibits the growth of bacterial plaque in hard-to-reach places, protecting teeth and gums. Contains stannous fluoride and sodium fluoride, which support protection against caries and strengthen the enamel. The product has a pleasant mint flavor that increases the feeling of cleanliness and freshness after washing. Oral-B Pro-Expert Advance Science toothpaste is intended for adults and adolescents over 12 years of age.