NAME NEMEX 21.62 MG/G PASTE FOR ORAL ADMINISTRATION FOR DOGS ACTIVE INGREDIENTS Pyrantel pamoate 21.62 mg/g (equivalent to 7.5 mg/g pyrantel base). EXCIPIENTS Precipitated silica, propyl parahydroxybenzoate, methyl parahydroxybenzoate, sorbitol solution, sodium alginate, purified water. THERAPEUTIC INDICATIONS It is indicated for the treatment and prevention of ascaris and hookworm infestations in puppies and adult dogs. CONTRAINDICATIONS / ADVERSE EFFECTS Do not use in cases of hypersensitivity to the active ingredient or to any of the excipients. DOSAGE 14.5 mg pyrantel pamoate equal to 5 mg pyrantel base per kg body weight of the dog. Directions for use: For ease of use, depending on the packaging used, the following dose is recommended. 16 g syringe: one syringe mark for every 2 kg of body weight. 10 g tube and 24 g tube: two cm of paste for every kg of body weight. It must be administered in a single dose, without fasting the dog or following a specific diet. The palatability of Nemex allows it to be distributed directly into the dogs mouth or, in the case of unsociable animals, mixed with food. Prophylaxis: Prophylaxis is used to keep the dog free of roundworms and to prevent the risk of infestation in humans (especially children) by dogs with roundworms. In addition, prophylactic treatment allows the dog to: be more resistant to other diseases; tolerate fatigue better, resulting in better performance; have a more alert sensorium; and have a better general appearance, in particular with a shinier coat. Prophylaxis program: 1. Puppies: one treatment at the age of 10-14 days, repeated between the 4th and 8th week of age. It is particularly important to remember the paramount importance of the pre-vaccination treatment, since the presence of parasites can interfere with the establishment of a solid vaccine immunity. 2. Bitches: one treatment 15 days before mating; a second treatment one week before calving; a third treatment 4 weeks after calving. This series of treatments aims to prevent the infestation of puppies during gestation and subsequently, after calving, through colostrum and milk sucked from the mother in the first days of life. 3. Show dogs: one treatment 15-20 days before the show. 4. Hunting dogs: one treatment 15-20 days before the hunting season. 5. All other dogs: one treatment in early spring, repeated in early autumn. Treatment of roundworm and hookworm infestations: Treatment should be administered immediately whenever the presence of parasites is confirmed and repeated after 2-3 weeks. STORAGE: Do not store above 25 degrees C. Shelf life after first opening the immediate packaging: Use immediately. WARNINGS: If dosing is difficult, for example if the dog cannot be weighed, the dose of Nemex should be rounded up. The preparation does not exert its full therapeutic efficacy below the recommended dose; however, high doses have no contraindications. Parasitic resistance to any class of anthelmintic may develop after frequent and repeated use of an anthelmintic of that class. To achieve effective parasite control, treatment should be based on the results of a faecal parasitological examination. The product has a wide margin of safety and can be safely administered to subjects of all ages, in any physiological state (including pregnant and lactating females) and in any state and severity of the disease. Special precautions to be taken by the person administering the veterinary medicinal product to animals: Avoid contact with skin and eyes. Wash skin that comes into contact with the product with water. Use gloves in case of hypersensitivity to the active substance or to any of the excipients. Overdose: The product has an excellent safety profile and an overdose is unlikely to cause adverse reactions in puppies, pregnant or lactating females or adult dogs. Even when administered at doses 40 times higher than the therapeutic dose and for several days, no symptoms of intolerance (vomiting, weight loss) are observed. TARGET SPECIES: Dogs. INTERACTIONS: Do not use concomitantly with other cholinergics or cholinesterase inhibitors. Piperazine antagonizes the effect of pyrantel. DIAGNOSIS AND PRESCRIPTION: Veterinary medicinal product available without a prescription. ADVERSE REACTIONS: None known. PREGNANCY AND BREAST-FEEDING: The product is specifically indicated for use during pregnancy and breast-feeding. No adverse reactions have been observed or reported in clinical trials using doses higher than those recommended