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Yabro Spray-sol 9 mg/5 ml - 0.18% Sodium Hyaluronate Description Yabro Spray-sol allows the nebulization of the Yabro vial, via the Spray-sol device. Spray-sol is a medical device specifically designed for topical treatments of the nasal and sinus cavities. It allows for rapid administration of the solution through nebulization in particles ranging from 10 to 20 microns in size, ideal for treating the upper airways. Thanks to its conical shape, Spray-sol adapts ergonomically to the nostrils of adults and children. Yabro Spray-sol is indicated in the adjuvant treatment of upper respiratory tract conditions such as: tonsillitis, laryngitis, pharyngitis, nasopharyngitis, sinusitis, rhinitis, tracheitis, both in the acute and chronic phase; hoarseness; inflammation of the vocal cords with and without dysphonia; to improve the restoration of mucosal function in the post-operative phase of endonasal interventions. Yabro Spray-sol is in addition to and does not replace other therapeutic treatments that may be prescribed to patients. Hyaluronic acid is universally recognized as the main molecular component of the extracellular matrix. In the respiratory system, it is synthesized by fibroblasts in the nasopharynx and pulmonary interstitium, by glands in the tracheobronchial submucosa, and by goblet cells of the lining epithelium, which add it to the mucus that lines and protects the airways. Thanks to this distribution, hyaluronic acid plays a central role in respiratory physiology, intervening in multiple homeostatic mechanisms. Nebulized hyaluronic acid rapidly penetrates and integrates into the pulmonary interstitium, preventing the diffusion of macromolecules and regulating the migration of cell populations involved in inflammatory reactions. Its high hydrophilicity also allows for hydration of the entire respiratory tract, facilitating the removal of catabolites and allergens. Thanks to its ability to integrate into the glycoprotein component lining the prerespiratory mucosa, it plays a role in regulating mucociliary clearance by interfering with potential allergens, inflammatory factors, whether environmental or endogenous. Components Each vial contains: sodium hyaluronate (hyaluronic acid sodium salt), water, sodium chloride. How to use We recommend taking 1 5 ml vial once or twice a day, as advised by your doctor, for a period of at least 2 weeks. Open the single-dose vial by breaking the neck along the highlighted line. Tightly screw the needle onto the syringes Luer closure collar, both included in the package, and aspirate the solution to be nebulized. Unscrew the needle and, after capping it, place it in the appropriate container. Place the syringe, filled with the solution to be nebulized, into the Spray-sol inlet nozzle. Secure the syringe by tightly screwing the Luer closure collar onto the Spray-sol inlet nozzle. Insert the Spray-sol dispenser into one nostril to prepare for nebulization. When nebulizing with Spray-sol, it is recommended to keep your torso upright and not tilt your head in any direction. Inhale and firmly push the syringe plunger to nebulize the solution, taking care to divide the solution in the syringe evenly between both nostrils. Release the syringe plunger before exhaling. Repeat the steps for the other nostril. Cleaning Spray-sol: Spray-sol is intended for single-patient use, but can be used multiple times. Therefore, it is very important to thoroughly clean the device after each use to ensure its longevity and proper functioning. Wash Spray-sol under warm running water, possibly adding a little mild (non-abrasive) soap, or wash in the dishwasher on the hot cycle. Before storing Spray-sol, dry it thoroughly with a soft cloth or a jet of hot air. Warnings Do not use Yabro Spray-sol after the expiry date shown on the package. Do not use Yabro Spray-sol if the packaging is open or damaged. For proper use of Yabro Spray-sol, the patient must be in an upright position. Do not tilt the head in any direction or lie down to use Yabro Spray-sol. Yabro vials are sterile and intended for single use only. Do not reuse to avoid any risk of contamination and do not re-sterilize. Once opened, Yabro vials must be used immediately and discarded after use. Before each use, check that the Spray-sol device is not damaged; if the Spray-sol is damaged, do not use it for nebulization. Spray-sol is intended for a single patient, but can be reused for multiple nebulizations. To reuse, clean according to the instructions. The Spray-sol device should be used for no more than 100 sprays and in any case for no longer than one month. The needle and syringe are intended for multiple use. After each use, cap the needle and store it and the syringe in the appropriate container. The use of Yabro Spray-sol by children or non-self-sufficient people must take place under the supervision of an adult who has read these instructions for use. Yabro Spray-sol is an additional treatment and does not replace other treatments prescribed by your doctor. It is advisable to consult your doctor before using Yabro Spray-sol. Smoking compromises the protective effect of hyaluronic acid on alveolar function. Keep out of the reach and sight of children. Spray-sol is a device not suitable for use in the presence of a flammable anaesthetic mixture with oxygen or nitrous oxide. The product should not be used in cases of known hypersensitivity to sodium hyaluronate or other ingredients. If side effects occur, discontinue use and consult your doctor. Conservation Store in a dry place, at a temperature between 0°C and 25°C. Keep away from hot surfaces and protect from sunlight. Do not freeze. Shelf life in intact packaging: 36 months. Format The package contains: - 10 sterile single-use 5 ml vials of Yabro. - 1 nebulization device: Spray-sol. - 1 x 5 ml luer lock syringe: Soft-ject syringe. - 1 sterican mix needle. Code 17807
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