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Tumor cells express a characteristic isoform of the key enzyme pyruvate kinase. This isoenzyme, Tumor M2-PK, enters the circulation and can be quantified in EDTA plasma using the ScheBo®-M2-PK™ assay. The development of Tumor M2-PK reflects the altered metabolic state of tumor cells. Therefore, the test can be used for various tumor types. The concentration of Tumor M2-PK correlates very well with tumor malignancy (staging). However, no correlation with histological grading was found. Studies of a wide variety of human tumors show that an isoenzyme of pyruvate kinase, type Tumor M2 (Tumor M2-PK), is found in elevated concentrations in tumors. A correlation exists between tumor malignancy and the level of this conceptually novel tumor metabolic marker, Tumor M2-PK. ScheBo®-Biotech has developed an enzyme immunoassay (ELISA) that can quantify tumor M2-PK in plasma. This test is based on two monoclonal antibodies that are highly specific for tumor M2-PK and therefore do not react with the other pyruvate kinase isoenzymes (types L, R, M1, and M2). First reliable tumor metabolic marker for renal cell carcinoma: In urology, the suitability of this new tumor metabolic marker has so far been clinically proven, among other things, in renal cell carcinoma. Since Tumor M2-PK is a specific protein and not organ-specific, the test is suitable for diagnosing a wide variety of tumor types. The test detects the following tumors: Renal cell carcinoma lung cancer gastric cancer esophageal cancer Cervical cancer breast cancer Colorectal cancer Pancreatic cancer Ovarian cancer - Test procedure Indications, High accuracy and sensitivity, Method, Sample material, Stability and shipping, Quick start guide
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