Retinol acetate: Benefits and uses Regular use of retinol acetate can significantly improve the appearance of skin aged by environmental factors. In particular, sun-induced hyperkeratosis can be significantly reduced. For best results, it is recommended to apply the Retin-A-cid cream in the evening after thoroughly cleansing the skin. It can also be gently massaged into affected areas as needed. Recommended use Apply a small amount of the cream to the affected areas of skin in the evening or as needed, and massage it in gently. Please note that the product may stain due to its high carotene content. For external use only