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PHYTONOTTE ALL NIGHT Description A dietary supplement based on magnesium and plant extracts that supports normal biorhythms and promotes sleep, prolonging nightly rest and reducing the time it takes to fall asleep and the frequency of nighttime awakenings. It also relieves tension and promotes relaxation, contributes to the normal functioning of the nervous system and allows the regaining of harmony and tranquility, improving overall well-being and quality of life. Property Jujube : Its fruit is mainly used as a food for its nutritional properties. Its seeds are used to treat anxiety and insomnia and have been shown to be particularly effective in the first phase of sleep. The secondary metabolites of jujube modulate GABAergic activity and the serotoninergic system, and its sedative effect has been shown to be mainly due to saponins. Griffonia : Contains a high amount of 5-hydroxytryptophan (5-HTP), a precursor to serotonin, which, unlike exogenous tryptophan, easily crosses the blood-brain barrier. Griffonia also combats depression and anxiety without side effects and is non-addictive. Valerian : The most important components of valerian are valerenic acids, valeranone, valerenal and borneol esters; in particular, bornyl acetate and bornyl isovalerate, valerenic acid, hydroxyvalerenic acid and acetoxyvalerenic acid are found. Valerian has sedative and muscle relaxant properties, counteracts the somatic effects of stress and slightly improves concentration. It reduces the time required to wake up and fall asleep, consolidates sleep and improves the quality of sleep (approximately twice) without causing drowsiness upon awakening. It is particularly indicated for stressful situations and during periods of intense psychophysical activity. It is also particularly effective during menopause for treating anxiety, stress and insomnia. It also seems to be effective in improving sleep quality in people who reduce or completely discontinue the use of benzodiazepines. Magnesium : An essential mineral, the total body content is approximately 25 grams: 70% is found in the bones, while the remaining 30% is found in soft tissues and fluids. It is essential for the proper functioning of over 300 enzymes. Among its various functions, it promotes nerve conduction and exerts a calming, sedative and relaxing effect on neuronal cells. When deficient, nerve cells do not transmit messages well and enter a state of hyperexcitability. Several studies have also shown that magnesium supplementation improves the quality and duration of sleep, sleep latency (the time it takes to fall asleep) and reduces early awakenings. ingredients Bulking agent: microcrystalline cellulose; magnesium oxide; anti-caking agents: hydroxypropylmethylcellulose, mono- and diglycerides of fatty acids, silicon dioxide, magnesium salts of fatty acids; valerian root extract (Valeriana officinalis L.) tit. 0.8% valerenic acids, jujube seed extract (Ziziphus jujuba Mill.) tit. 2% jujubosides, griffonia seed extract [Griffonia simplicifolia (DC.) Baill.] tit. 25% 5-hydroxytryptophan (5-HTP); glazing agents: hydroxypropylmethylcellulose, talc, polyethylene glycol; dyes: titanium dioxide, cupric complexes of chlorophylls, iron oxides and iron hydroxides. Nutritional characteristics Average values for 3 tablets Magnesium 450 mg (120% NRV*) Valerian is 525 mg Jujube is 300 mg Griffonia is 120 mg 5-HTP application. 30 mg *NRV: Nutritional Reference Values. How to use Take 1-3 tablets approximately 30-60 minutes before bedtime, swallowed with a little water. warnings Do not use during pregnancy and breastfeeding. Avoid concomitant use of L-tryptophan, antidepressants and antihistamines and in case of renal failure. Conservation Store at room temperature. Shelf life in intact packaging: 36 months. Format Pack of 30 tablets. Code 180225 Bibliography Abbasi B. et al. “Effect of magnesium supplementation on primary insomnia in the elderly: A double-blind, placebo-controlled clinical trial.” J. Res. Med. Sci. 17(12):1161-9. 2012. Kim J. et al. “Individual plant natural products as sleeping pills: a systematic review.” J. Med. Food. 21(5):433-444. 2018. Lemaire PA et al. An HPLC method for the direct analysis of the serotonin precursor, 5-hydroxytrophan, in Griffonia simplicifolia seeds. Phytochem. Anal. 13(6): 333-7. 2002. Mineo L. et al. Valeriana officinalis root extract modulates cortical excitatory circuits in humans. Neuropsychobiology. 75(1):46-51. 2017. Roh D. et al. “Valerian extract alters functional brain connectivity: a randomized, double-blind, placebo-controlled study.” Phytother Res. 10 Jan. doi: 10.1002/ptr.6286. 2019. Sahu S. et al. Valeriana wallichii root extract improves sleep quality and modulates brain monoamine levels in rats. Phytomedicine. 19(10):924-9. 2012. Shergis JL et al. Ziziphus spinosa seeds for insomnia: a review of chemistry and psychopharmacology. Phytomedicine. 34:38-43. 2017
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