CICASTELA REPAIRING CREAM Description Cicastela Repair Cream is suitable for newborn and infant skin, starting from birth, for localized daily superficial redness. -Promotes excellent skin repair. -Soothes immediately and for a long time. -Purifies the skin. -Protects the skin barrier and preserves the skins cellular capital. -91% ingredients of natural origin. Its gentle formula doesnt sting when applied. Its highly tolerable and dermatologically tested. -Avocado perseose: patented natural active ingredient, protects the skin barrier and preserves the skins cellular richness. -Hyaluronic acid: promotes skin repair. -Panthenol: immediately and long-lastingly soothes discomfort. -Copper-zinc: prevents the risk of superinfection. Components Aqua (Water), caprylic/capric triglyceride, C10-18 triglycerides, panthenol, glycerin, triisostearin, Butyrospermum parkii (Shea) butter, polyglyceryl-3 distearate, Ricinus communis (Castor) seed oil, 1,2-hexanediol, cetearyl alcohol, potassium cetyl phosphate, polyacrylate crosspolymer-6, allantoin, glyceryl caprylate, glyceryl stearate citrate, hydrogenated castor oil, hydrolyzed hyaluronic acid, xanthan gum, copper PCA, zinc PCA, sodium hydroxide, Persea gratissima (Avocado) fruit extract, citric acid. How to use Areas of application: lip contour, dry patches, skin folds, diaper rash, abrasions, traces of chickenpox, insect bites. The creams barrier-effect texture leaves a non-greasy protective film. Skin regains softness and elasticity. Application is made easy by the cannula tube, which allows for precise application. Conservation Shelf life in intact packaging: 36 months. Shelf life after opening: 6 months. Format 40ml cannula tube. Bibliography -Effect of AV119, a natural sugars from avocado, on malassezia furfur invasiveness and on the expression of HBD-2 and cytokines in human keratinocytes. Donnarumma J, Buommino E, Baroni A, Auricchio L, De Filippis A, Cozza V, Piccardi N, Msika P, Tufano MA EXPERIMENTAL DERMATOLOGY, 2007; 16(11): 912-9 . -Patented natural avocado sugars modulate the HBD-2 expression in human keratinocytes through the involvement of protein kinase c and protein tyrosine kinases. Paoletti I, Buommino E, Tudisco L, Baudouin C, Msika P, Tufano MA, Baroni A, Donnarumma G archives of dermatological research, 2010; 302(3): 201-9. -Functional skin adaptation in infancy - almost complete but not fully competent. Fluhr JW, Darlenski R, Taieb A, Hachem JP, Baudouin C, Msika P, De Belilovsky C, Berardesca e experimental dermatology, 2010; 19(6): 483–92. -AV119, a natural sugar from avocado gratissima, modulates the LPS-induced proinflammatory response in human keratinocytes. Donnarumma G, Paoletti I, Buommino E, Fusco A, Baudouin C, Msika P, Tufano MA, BaronI A inflammation, 2011; 34 (6): 568-575. -Adaptation of naissance skin to childhood: practical considerations. Fluhr JW, DarlenskI R, Taieb A, Hachem JP, Baudouin C, Msika P, De Belilovsky C, Berardesca E les nouvelles dermatologiques, 2011; 30(4): 229-32. -Infant epidermal skin-physiology: adaptation after birth. Fluhr JW, Darlenski R, Lachmann N, Baudouin C, Msika P, De Belilovsky C, Hachem JP British journal of dermatology, 2012; 166(3):483-90. -Skin physiology adaptation in infants Fluhr et al BJD Editors choice Journal of investigative dermatology, 2012; 132: P132. -Patented natural avocado sugar modulates the HBD-2 and HBD-3 expression in human keratinocytes through toll like receptor-2 and erk/mapk activation. Paoletti I, Buommino E, Fusco A, Baudouin C, Msika P, Tufano MA, Baroni A, Donnarumma G Archives of dermatological research, 2012; 304(8): 619-625. -Effects of a patented natural sugar on M.Furfur pathogenicity and HBD2 expression. Buommino E, Donnarumma G, Orlando M, Auricchio L, De Filippis A, Piccardi N, Msika P, Tufano MA Journal of investigative dermatology, August 2006; volume 126, issue S3, page S52, abstract 299. -Avocado sugars are effective inducer of cutaneous defensive functions Bredif S, Garnier S, Piccardi N and Msika P. Journal of investigative dermatology, April 2007; volume 127, issue S1, page S69, abstract 413. -Is the functional skin adaptation complete and competent in infancy? Fluhr JW, Darlenski R, Hachem JP, Baudouin C, Msika P, De Belilovsky C, Berardesca E. Journal of investigative dermatology, April 2011; volume 131, issue s1, page s46, abstract 274. -Comparison of the skin physiology of newborns and young children with that of adults: a randomized clinical trial. Fluhr JW, Lachmann N, Baudouin C, Williams R, De Belilovsky C, Hachem Jp, Msika P. Journal of investigative dermatology, April 2011; volume 131, issue s1, page s81, abstract 481. -Skin adaptation from birth to childhood: practical considerations. Fluhr JW, Darlenski R, Hachem JP, Baudouin C, Msika P, De Belilovsky C, Berardesca E. Journal of the american academy of dermatology, February 2011; volume 64, issue 2, supplement 1, page AB136. -Ability of natural avocado sugars to prevent cutaneous inflammation. Bredif S, Buommino E, Tufano Ma, Baudouin C, Paoletti I, Garnier S, Baroni A, Msika P. Journal of investigative dermatology, september 2011, volume 131, issue s2, page s9, abstract 054. -Patented avocado sugars modulate HBD-2 expression in human keratinocytes through toll-like-receptor-2. Paoletti I, Buommino E, Donnarumma G, Baroni A, Baudouin C, Msika P and Tufano Ma. Journal of investigative dermatology, september 2011, volume 131, issue s2, page s85, abstract 510. -Skin physiology and surface isotropy investigations in young children of different age groups compared to adults: (EMI) score. Fluhr JW, Baudouin C, De Belilovsky C, Hachem JP, Darlenski R, Lachmann N, Msika P. Journal of the american academy of dermatology, april 2013, volume 68 (n°4), supplement 1, page ab177, abstract P6883. -Molecular biomarkers analysis to characterize epidermis of infants. Baudouin C, Brédif S, Pedretti N, Barrault C, Bernard FX and Msika P. Journal of investigative dermatology, may 2013; volume 133, issue s1, page s106, abstract 622. -Avocado perseose, a biomimetic active ingredient for the protection and accompaniment of infants skin. Leclère-Bienfait S, Rocheteau J, Brédif S, Baudouin C, Saunois A and Msika P. Journal of investigative dermatology, may 2013; volume 133, issue s1, page s106, abstract 623.