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Histamine is a biogenic amine formed from the amino acid histidine and is classified as a tissue hormone. If histamine breakdown is not functioning optimally, especially when large amounts of histamine accumulate and the histamine-degrading enzymes, such as diamine oxidase (DAO) and histamine N-methyltransversase (HNMT) produced in the liver, are not functioning properly, an excessive amount of histamine can build up in the body. Histamine intolerance (HIT) is therefore an expression of an imbalance between histamine production and histamine breakdown. Factors influencing histamine levels in the body include not only histamine-containing foods, but also, for example, an overgrowth of histamine-producing bacteria in the gut, allergies, or medications that can inhibit histamine breakdown. Typical symptoms of histamine intolerance can be varied. An excess of histamine can trigger circulatory problems, headaches, respiratory difficulties, allergy-like symptoms, and skin rashes. Gastrointestinal issues such as stomach pain, heartburn, cramps, bloating, and diarrhea can also occur. This urine test measures the levels of histamine and its breakdown products in the urine. Histamine is primarily broken down in the intestine by the enzyme diamine oxidase (DAO) into imidazole acetaldehyde and imidazole acetic acid. As a secondary degradation pathway, it is metabolized intracellularly by the enzyme N-methyltransferase to the breakdown products N-methylhistamine, N-methylimidazole acetaldehyde, and N-methylimidazole acetic acid. The ratios between N-methylhistamine and histamine, and between imidazole acetic acid and histamine, provide insights into the function of DAO and the activity of HNMT, respectively. The following parameters are examined: histamine Imidazole acetic acid imidazoleacetic acid/histamine ratio N-Methylhistamine N-Methylimidazoleacetic acid Ratio N-methylhistamine/histaminediagnosis The results serve as a basis for individual therapy, which should only be carried out after consultation with a doctor or therapist. The test kit includes: 1 Instructions for sample collection 1 urine cup 1 yellow urine collection tube (urine monovette) 1 yellow tip 1 shipping container for urine monovette 1 shipping bagHow does the ordering process work? After you place your order, we will send you the requested test kit along with detailed instructions. You place your sample in a tube, send it in a pre-addressed envelope to our partner laboratory, GANZIMMUN Diagnostics GmbH, and receive your results with an evaluation of your profile within approximately 4-7 business days. Please note that reimbursement by private health insurance is not always guaranteed for this test. Therefore, please check with your health insurance provider to see if the costs are covered.
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Vânzător: Liki24.co.uk
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