Triple action mechanism for urinary health. Its formula includes American cranberry, PACs, mannose and a probiotic that work synergistically to prevent recurrent urinary tract infections. > American cranberry PACs inhibit bacterial adhesion to the urinary tract wall by blocking type 1 (mannose-sensitive) and type P (mannose-resistant) fimbriae. > Mannose inhibits bacterial adhesion by selectively blocking type 1 fimbriae. > The probiotic Lactobacillus rhamnosus stimulates the bodys defense mechanisms and maintains the vaginal pH at appropriate levels (between 4 and 4.5). Composition D-Mannose, L-ascorbic acid (vitamin C), cranberry extract (Vaccinium macrocarpon L.), hibiscus extract (Hibiscus sabdariffa L, flower), L-rhamnosus (100Bc ufg(g), anti-caking agents: silicon dioxide (E551) and magnesium stearate (E470b). Instructions for use Take two capsules a day. One capsule in the morning and one in the evening, the last one before bed and after urinating. ingredients D-Mannose, L-ascorbic acid (vitamin C), cranberry extract (Vaccinium macrocarpon L.), hibiscus extract (Hibiscus sabdariffa L, flower), L-rhamnosus (100Bc ufg(g), anti-caking agents: silicon dioxide (E551) and magnesium stearate (E470b). Nutritional value Vitamin C (317 mg), L-Rhamnosus (8 μg - 800,000 CFU), American Cranberry (230 mg), Proanthocyanidins from PAC extract (57.6 mg), D-Mannose (650 mg) and Hibiscus extract (47.6 mg). CFU: Colony Forming Units. Pharmaceutical advice There are no contraindications for continuous administration of ISTIVEN.