ACTION AND MECHANISM - Vasodilator. Ginkgo leaves appear to improve cerebral and peripheral blood flow due to possible vasodilatory and antiplatelet effects, improving the rheological properties of the blood. The exact mechanism and the active ingredients responsible are unknown, although it is postulated that they could be flavonoids, such as quercetin, and terpenoids such as ginkgolides and bilobalides. SPECIAL WARNINGS - Discontinue treatment at least 2 weeks before scheduled surgery due to the risk of increased bleeding time. PATIENT ADVICE - Tell your doctor and/or pharmacist if: * Symptoms continue or worsen during ginkgo use. * She is going to undergo surgery. CONTRAINDICATIONS - Hypersensitivity to ginkgo or any other component of the medication. ADVANCED AGE No specific problems have been described in the elderly that would require a dosage adjustment. EFFECTS ON DRIVING It does not appear to have significant effects. PREGNANCY Animal safety : no data available. Safety in humans : There are no adequate and well-controlled studies in humans. Its administration is not recommended. Effects on fertility : no specific studies have been conducted in humans. INDICATIONS - Symptomatic treatment of mild disorders resulting from cerebral circulatory disturbances, such as [VERTIGO], [DIZZINESS] or [TINNITUS], or from the lower extremities such as [MUSCLE CRAMPS] or [COLD EXTREMITIES]. INTERACTIONS - Antiplatelet drugs. Ginkgo may increase the risk of bleeding when combined with antiplatelet drugs. LACTATION Animal safety : no data available. Safety in humans : It is unknown whether it is excreted in breast milk, and the potential consequences for the infant. Its administration is not recommended. CHILDREN Safety and efficacy have not been evaluated in children and adolescents < 18 years, therefore its use is not recommended. GUIDELINES FOR PROPER ADMINISTRATION - Capsules: swallow with a sufficient amount of liquid. Administration with food : can be taken with or without food. POSOLOGY “GINKGO ARKOPHARMA DOSAGE” - Adults: 2 capsules, 3 times a day, with breakfast, lunch and dinner. - Children and adolescents < 18 years: not recommended. - Elderly: no specific dosage recommendations have been made. Treatment duration : 6-8 weeks. Missed dose : Take the missed dose as soon as possible, unless it is almost time for the next dose. Take the next dose at the usual time. Do not double the next dose. DOSAGE IN HEPATIC INSUFFICIENCY No specific dosage recommendations have been made. DOSAGE IN RENAL INSUFFICIENCY No specific dosage recommendations have been made. PRECAUTIONS - [COAGULATION DISORDERS]. Ginkgo may increase the risk of bleeding, so caution is advised in patients with coagulation disorders or [HEMORRHAGE]. Stop treatment at least 2 weeks before surgery. - [EPILEPSY]. It cannot be ruled out that it could increase the risk of [SEIZURES]. ADVERSE REACTIONS Adverse reactions are usually mild and transient. Adverse reactions are described according to each frequency interval, being considered very common (>10%), common (1-10%), uncommon (0.1-1%), rare (0.01-0.1%), very rare (<0.01%) or of unknown frequency (cannot be estimated from the available data). - Immune system disorders: frequency unknown [HYPERSENSITIVITY REACTIONS], with [ERYTHEMA] or [PRURITUS]. - Nervous system disorders: frequency unknown [HEADACHE], [DIZZINESS], [VERTIGO]. - Gastrointestinal disorders: frequency unknown [DIARRHEA], [ABDOMINAL PAIN], [NAUSEA]. OVERDOSE Symptoms : no cases have been described. Measures to be taken : - Antidote: there is no specific antidote. - General disposal measures: none have been described. - Monitoring: patients clinical status. - Treatment: symptomatic.