PATIENT ADVICE - It is recommended to avoid continuous treatments longer than 2 weeks. - If after 7 days of treatment the patient does not improve, or if high fever, headache, nausea, vomiting or difficulty swallowing or breathing appears, it is advisable to consult a doctor and/or pharmacist. CONTRAINDICATIONS - Hypersensitivity to echinacea, sage, or any other component of the medication. Cases of cross-reactions have been reported between species of the Asteraceae family (chamomile, artichoke) or the Lamiaceae family (basil, spearmint, lemon balm, mint, oregano, rosemary, thyme), so its use is not recommended in patients who have had allergic reactions to any of these plants. - Diseases in which stimulation of the immune system could be dangerous, such as autoimmune diseases ([COLAGENOSIS], [MULTIPLE SCLEROSIS]), progressive systemic disorders ([TUBERCULOSIS], [SARCOIDOSIS]), [IMMUNODEFICIENCY] ([HIV INFECTION], primary or secondary immunosuppression), pathologies affecting white blood cells ([AGRANULOCYTOSIS], [LEUKEMIA]) or allergies ([URTICARIA], [ATOPIC DERMATITIS], [ASTHMA]). CONTRAINDICATIONS RELATED TO EXCIPIENTS This medicine contains soybean oil. Do not use if you have a soy allergy or peanut allergy. ADVANCED AGE No specific problems have been described in the elderly. PREGNANCY There are no adequate and well-controlled studies in humans. Its administration is only acceptable if there are no safer therapeutic alternatives, and the benefits outweigh the potential risks. INDICATIONS - Treatment of [PHARYNGITIS] associated with colds, chills or flu. Its use is based exclusively on traditional use. INTERACTIONS - Benzodiazepines. Sage has been reported to potentiate the effects of drugs such as benzodiazepines and barbiturates, which act on the GABA receptor. This combination should be avoided. - Immunosuppressants. Echinacea may decrease the clinical effects of drugs such as corticosteroids, cyclosporine, tacrolimus, or sirolimus. This combination should be avoided. LACTATION It is unknown whether it is excreted in breast milk, and what the consequences might be for the infant. It is recommended to discontinue breastfeeding or avoid administering it. CHILDREN Safety and efficacy have not been evaluated in children and adolescents under 18 years of age, therefore its use is not recommended. GUIDELINES FOR PROPER ADMINISTRATION Place the spray nozzle on the bottle and shake vigorously. Holding the bottle upright, direct the spray nozzle towards the back of the neck and press the valve. POSOLOGY - Adults: 2 sprays, 6-10 times a day. - Children and adolescents under 18 years of age: Safety and efficacy have not been evaluated. Duration of treatment : It is recommended to avoid continuous treatment for more than 2 weeks. If symptoms persist or worsen after 7 days of treatment, it is advisable to consult a doctor and/or pharmacist. PRECAUTIONS - Pharyngeal infections. It is recommended to consult a doctor if pharyngitis is accompanied by high fever, headache, nausea, vomiting, or difficulty swallowing or breathing. - Anaphylaxis. Cases of anaphylactic reactions to echinacea have been reported in atopic individuals. In case of any unusual adverse reaction, it is advisable to consult a doctor. If signs indicative of an anaphylactic reaction appear (dizziness, vertigo, palpitations, skin rash, hives), it is advisable to discontinue treatment and not restart it. PRECAUTIONS RELATING TO EXCIPIENTS This medication contains ethanol. It is recommended to check the composition to know the exact amount of ethanol per dose. * Amounts less than 100 mg/dose are considered small and are not usually harmful, especially in children. * Amounts exceeding 100 mg/dose may be harmful to people with [CHRONIC ALCOHOLISM], and should also be taken into account in pregnant and breastfeeding women, children, and high-risk groups, such as patients with liver disease ([LIVER FAILURE], [LIVER CIRRHOSIS], [HEPATITIS]) or [EPILEPSY]. * The amount of alcohol in this medicine (well below the limit of 3 g/dose) is not expected to impair the ability to drive or operate machinery, or interfere with the effects of other medicines. ADVERSE REACTIONS MedDRA classification of adverse reactions: very common (>10%), common (1-10%), uncommon (0.1-1.0%), rare (0.01-0.1%), occasional (<0.01%). - Digestive: Frequent oral mucosal rashes and burning sensation in the throat. - Allergic: The use of echinacea has been associated with cases of anaphylaxis, skin edema, angioedema, dizziness, bronchospasm, dyspnea, hypotension, and severe skin reactions such as Stevens-Johnson syndrome or Quinckes edema. Similarly, echinacea has been associated with exacerbations of autoimmune reactions such as disseminated encephalitis, erythema nodosum, immunothrombocytopenia, Evans syndrome, or Sjögrens syndrome. Topical application appears to result in a less severe allergic reaction. skin rashes, contact dermatitis, eczema and lip swelling. ADVERSE REACTIONS RELATED TO EXCIPIENTS This medicine contains sorbitol. Daily doses above 10 g of sorbitol taken orally may have a mild laxative effect and lead to diarrhea. OVERDOSE Symptoms: There is no clinical experience with the use of this medication. In cases of ingestion of quantities exceeding 15 g of leaves, tachycardia, hot flashes, vertigo, and seizures have been reported. Treatment: Symptomatic.