Biocanine External pesticides Permetrix Spot-on solution For large dogs over 25kg Permethrin Eliminates fleas and ticks Repels ticks, sand flies and mosquitoes Reduces the risk of transmission of canine leishmaniasis Veterinary medicine 3 pipettes of 4.0 ml Prevention and treatment of flea infestations (Ctenocephalides felis). Fleas on the dog are killed within a day of treatment. A single treatment prevents flea reinfestation for 4 weeks. The product can be included in a treatment program for Flea Allergy Dermatitis (FAD) when the condition has been diagnosed by a veterinarian. The product has an acaricidal efficacy on ticks lasting 4 weeks (Rhipicephalus sanguineus and Ixodes ricinus) and 3 weeks (Dermacentor reticulatus) and a repellent efficacy on Ixodes ricinus lasting 3 weeks. Ticks already present on the dog at the time of treatment may not be killed in the two days following administration of the treatment and may remain attached and visible. It is therefore advisable to remove any ticks present at the time of treatment, to prevent them from attaching to the dog and making a blood meal. A single treatment provides repellent (anti-bubbling) activity against the midge Phlebotomus perniciosus for three weeks and against the mosquito Aedes aegypti for 7 days to 14 days after treatment. Reduces the risk of Leishmania infantum infection transmitted by sand midges (Phlebotomus perniciosus ) for up to 3 weeks. The effect is indirect thanks to the activity of the product on the carrier.