Intensive anti-blemish care for oily, acne-prone skin, tested on over 4,600 patients. With a unique expertise in microcomedones, Avène Dermatological Laboratories have now discovered the role of microinflammation in their development. Thanks to Comedoclastin™** with patented properties, the new Comedomed+, now enriched with Niacinamide, offers a complete action to combat imperfections at the source. Reduces pimples, blackheads and acne spots with 1 year* of anti-recurrence action. The formula is concentrated with dermatological active ingredients: - 25% Comedoclastin™**: with sebum-reducing activity, reduces imperfections. - 4% Niacinamide: improves the appearance of pores and reduces acne spots. With soothing Avène Thermal Spring Water. A light, hydrating gel-cream texture that absorbs quickly with a non-greasy finish. Apply morning and evening to skin previously cleansed with Cleanance cleanser. Use from age 9, alone or in combination with an acne medication. *Limits the recurrence of blemishes. Clinical score, 2 applications per day for 12 months, 51 subjects. **Patent pending. Composition AVENE THERMAL WATER (AVENE AQUA). ISOPROPYL ALCOHOL. PEG-6. GLYCERIN. NIACINAMIDE. SILYBUM MARIANUM FRUIT EXTRACT. SILICA. POLYACRYLATE-13. POLYISOBUTHENE. POLYSORBATE 20. SORBITAN ISOSTEARATE. WATER (AQUA) Instructions for use Apply morning and evening to cleansed skin with a Cleanance cleanser. Can be used alone or in combination with an acne medication. ingredients AVENE THERMAL WATER (AVENE AQUA). ISOPROPYL ALCOHOL. PEG-6. GLYCERIN. NIACINAMIDE. SILYBUM MARIANUM FRUIT EXTRACT. SILICA. POLYACRYLATE-13. POLYISOBUTHENE. POLYSORBATE 20. SORBITAN ISOSTEARATE. WATER (AQUA) Pharmaceutical advice 3 times a day