For the stabilization of hyperthyroidism in cats prior to surgical thyroidectomy. For the long-term treatment of hyperthyroidism in cats. Ingredients per ml: Thiamazole 5 mg. Excipients: Sodium benzoate 1.5 mg. Intended for: Cats. Method of administration: Oral administration. Presentation form: 30 ml bottle. Dosage: For the stabilization of feline hyperthyroidism prior to surgical thyroidectomy and for the long-term treatment of feline hyperthyroidism, the recommended initial dose is 5 mg (1 ml of product) per day. Whenever possible, the total daily dose should be divided into two doses and administered in the morning and evening. Hematology, biochemistry, and serum total T4 should be evaluated before initiation of treatment and after 3 weeks, 6 weeks, 10 weeks, 20 weeks, and every 3 months thereafter. At each of the recommended monitoring intervals, the dose should be adjusted based on total T4 and clinical response to treatment. Dose adjustments should be made in 2.5 mg increments and the goal should be to achieve the lowest dose. If more than 10 mg per day is required, animals should be carefully monitored. The dose administered should not exceed 20 mg/day. For long-term treatment of hyperthyroidism, the animal must be treated for life. Possible adverse effects: Adverse reactions have been reported after long-term control of hyperthyroidism. In many cases, the signs may be mild and transient and are not a reason for discontinuation of treatment. The most serious effects are mainly reversible when the medication is stopped. The most common clinical side effects reported include vomiting, inappetence/anorexia, lethargy (extreme fatigue), severe pruritus and excoriations of the head and neck, bleeding tendency and jaundice associated with hepatopathy, and hematological abnormalities (eosinophilia, lymphocytosis, neutropenia, lymphopenia, mild leukopenia, agranulocytosis, thrombocytopenia or hemolytic anemia). These side effects resolve within 7-45 days after discontinuation of thiamazole therapy. Possible immunological side effects include anemia, with rare side effects including thrombocytopenia and serum anti-nuclear antibodies, and, very rarely, lymphadenopathy. Treatment should be stopped immediately and alternative therapy considered after an adequate recovery period. After long-term treatment with thiamazole in rodents, an increased risk of neoplasia in the thyroid gland has been shown, but no evidence is available in cats. If you notice any side effects, even those not already included in this leaflet, or you think that the medicine has not had any effect, please inform your veterinarian. Precautions: Do not use in cats suffering from systemic diseases such as primary liver disease or diabetes mellitus. Do not use in cats showing signs of autoimmune disease. Do not use in animals with white blood cell disorders such as neutropenia and lymphopenia. Do not use in animals with platelet disorders and coagulopathies (especially thrombocytopenia). Do not use in cats with hypersensitivity to thiamazole or the excipient sodium benzoate. Do not use in pregnant or lactating females. Concomitant treatment with phenobarbital may reduce the clinical efficacy of thiamazole. Thiamazole is known to reduce hepatic oxidation of benzimidazoles for helminths and may lead to increases in their plasma concentrations when given concomitantly. Thiamazole is an immunomodulator, therefore this should be taken into account when considering vaccination programs. Since thiamazole is a human teratogen, women of childbearing age should wear disposable, impermeable gloves when administering the product or handling litter/vomit from treated cats. If you are pregnant, think you may be pregnant or are planning to become pregnant, you should not administer this product or handle the litter/vomit of treated cats. Storage method: Store in a place protected from moisture and direct sunlight, at temperatures up to 25°C. Shelf life after first opening the bottle: 6 months. Product compliance information Product compliance information Product safety Manufacturer information Personal information Product safety information Currently, product safety information is not available. Manufacturer information Currently, manufacturer information is not available. Responsible person information Currently, information about the person responsible is not available. n Size: Small, Medium, Large Age: Junior, Adult, Senior Presentation type: Bottle Action: Thyroid Brand Name: Boehringer Ingelheim n Quantity: 30 ml