STORAGE AND EXPIRATION Store in a cool, dry place. INGREDIENTS Per tablet: Stabilizer: microcrystalline cellulose; hydroxypropyl methylcellulose; magnesium stearate; stearic acid; Valeriana officinalis L. root dry extract 100 mg; Passiflora incarnata L. aerial parts dry extract 100 mg; L-tryptophan; zinc gluconate; anti-caking agent: silicon dioxide; melatonin 1.99 mg; pyridoxine hydrochloride; color: titanium dioxide. Melatonin 1.99 mg Passiflora incarnata L.) 100 mg. Valeriana officinalis L 100 mg. INSTRUCTIONS FOR USE To help you fall asleep, take 1 tablet daily 1 to 2 hours before bedtime. It is recommended to take the tablet at the same time each day. To help relieve jet lag: On the first day of travel, take 1 tablet at night before going to bed. Repeat for several nights. OTHERS According to the Report of the Scientific Committee of the Spanish Agency for Consumer Affairs, Food Safety and Nutrition (AECOSAN) on the conditions of use of certain substances to be used in food supplements: Melatonin AECOSAN has proposed a maximum daily intake of melatonin of 1 mg. This proposal is based on the authorization of two health claims, in relation to the fact that melatonin contributes to • relieve the subjective feeling of jet lag: It can only be used with foods containing a minimum of 0.5 mg of melatonin per quantified portion. For a product to bear this claim, the consumer must be informed that the beneficial effect is obtained with a minimum intake of 0.5 mg, to be taken shortly before bedtime on the first day of travel and a few days after arrival at the destination (EU, 2012). • Melatonin helps reduce the time needed to fall asleep It can only be used with foods containing 1 mg of melatonin per quantified portion. For a product to bear this claim, the consumer must be informed that the beneficial effect is obtained with an intake of 1 mg of melatonin shortly before going to sleep (EU, 2012). Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone produced by the pineal gland of mammals and other organs, especially the enterochromaffin cells of the gastrointestinal tract and the retina (Hardeland et al., 1993) (Huether, 1993), whose main physiological function is the regulation or control of circadian and seasonal rhythms (Armstrong et al., 1986). It was discovered in the 1950s (Lerner et al., 1958, 1959). In recent years, it has been shown that melatonin also has numerous additional functions. It is produced and acts on numerous tissues or cells that express melatonin receptors, at much lower levels (Hardeland, 2009). Melatonin receptors MT1 and MT2 (membrane receptors) have been detected in numerous tissues of the CNS (Central Nervous System), in peripheral organs such as the gastrointestinal tract, liver, lung, skin, adrenal gland, gonads, male organs, breast tissue, kidney, heart, blood vessels, adipose tissue, neutrophils, lymphocytes and lymphoid tissue (Ishii et al., 2009). Both receptors involve signaling through cAMP inhibition, protein kinase A activity, effects on phospholipase A2 and C, and effects on potassium and calcium channels (Mathes, 2010). A third receptor, MT3, has also been described, which is an enzyme identified as quinone reductase 2. Deficiencies in melatonin production or receptor expression, or decreases in melatonin levels (such as those that occur with age) cause numerous dysfunctions. In these cases, with insufficient melatonin levels or poor melatoninergic signaling, numerous pathophysiological alterations can occur, reflecting the molecules pleiotropy. For example, decreased nocturnal melatonin levels have been repeatedly observed in patients with neurodegenerative disorders and sleep disturbances (Uchida et al., 1996). PRECAUTIONS AND WARNINGS Food supplements should not be used as a substitute for a balanced diet. Do not exceed the recommended daily dose. Keep out of reach of children. Vitamins and Minerals Per tablet: Vitamin B6: 1.4 mg. Zinc: 10 mg. L-tryptophan: 100 mg.