Pineapple Bromelain Drain Description Concentrated food supplement based on bromelain extracted from pineapple, with high enzymatic activity and enriched with SOD to counteract damage caused by oxidative stress. Promotes the drainage of body fluids, supports microcirculation function and reduces cellulite, improving skin tone and firmness. It also has a significant anti-inflammatory effect and, when taken after meals, aids digestion even after large meals. Property Pineapple: 90% water, but also contains sugars, essential oil, organic acids (especially oxalic, citric and malic), vitamins A, B and C, amino acids, fiber and minerals (especially iron, calcium, manganese and potassium). Bromelain is concentrated in the fruit, but especially in the stem that supports it. This enzymatic mixture of proteases, phosphatases, peroxidases, amylases and cellulases is the basis of all the biological activities recognized in the extract. Bromelain is active in a very wide pH range, between 4.5 and 9.5, is rapidly absorbed from the intestine and has a half-life of approximately 6-9 hours. Its proteolytic activity is predominant, justifying its use as a postprandial digestive adjuvant. Due to characteristics similar to those of pepsin, it is in fact able to accelerate the digestion of proteins, preventing the formation of intestinal gas and the feeling of abdominal heaviness. Another benefit for foot health comes from the antiplatelet activity of bromelain, the administration of which also results in reduced platelet activation. As a fibrinolytic, it inhibits the formation of thrombi and can be successfully used in acute thrombophlebitis. It can also help reabsorb hematomas. Due to its high concentration of antioxidant molecules, pineapple extract can also contribute to cardiovascular health, preventing the formation of atherosclerotic plaques in people with high cholesterol levels. Finally, pineapple stem possesses an anti-inflammatory effect whose mechanism is not fully understood, probably dependent on the proteolytic modulation of the molecular cascade underlying the inflammatory process. In addition to helping treat inflammatory conditions associated with trauma and edema, due to its effect on the immune response, it also shows promise in the management of chronic conditions such as asthma, sinusitis and rheumatoid arthritis, where it reduces inflammation and the infiltration of eosinophils and leukocytes. It is also used in pain management: it dose-dependently reduces acute knee pain in osteoarthritis and postoperative pain and edema. Superoxide dismutase: A crucial antioxidant present in almost all cells exposed to oxygen. It is the key enzyme that inactivates superoxide, the most reactive radical species that can damage membrane lipids, proteins, and DNA. SOD has been used for years in general medicine to manage anti-inflammatory conditions such as osteoarthritis, sports injuries, and knee osteoarthritis. It is also used to protect against cardiovascular risk, protect DNA from oxidative stress damage, and counteract excess free radicals caused by exercise. It also improves cognitive function, is useful in stress management, and may have immunoprotective effects. -SuperOx-D: is a patented extract obtained from carrot that acts by inactivating the peroxide radical and also other radical forms generated upstream and downstream through quenching mechanisms. -Centella: This Ayurvedic herb fights cellulite and supports healthy microcirculation. Specifically, it stimulates fibroblast activity and the synthesis of proline and alanine, amino acids essential for collagen formation. It normalizes perivascular connective tissue, improving the tone and elasticity of the venous walls. It also stimulates the cells and tissues involved in the healing process. ingredients Demineralized water, maltodextrin, inulin, bromelain from pineapple stem (Ananas comosus (L.) Merr.) 2,500 GDU/g, flavors; acidifiers: citric acid, malic acid; Superox-D superoxide dismutase 11,000 U/g from dry extract of carrot root (Daucus carota L.); preservatives: potassium sorbate, sodium benzoate; thickener: xanthan gum; dry extract of gotu kola leaves [Centella asiatica (L.) Urb.] tit. 2% triterpenes, dry extract of pineapple stem [Ananas comosus (L.) Merr.] tit. 0.1% bromelain; sweetener: steviol glycosides. Gluten free . Nutritional characteristics Average values ​​per 10 ml Energy 49.95 kJ 11.86 kcal FATS of which saturated of which monounsaturated of which polyunsaturated <0.01g <0.005g <0.005g <0.005g Carbohydrates of which sugars 2.43 grams 0.26g fiber <0.05g PROTEIN <0.01g Salt 9.15 mg Bromelain 500 mg Superoxide dismutase 20 mg Centella is 10 mg Pineapple is 10 mg How to use We recommend taking 10 ml per day, diluted in 250 ml of water, preferably in the morning to support drainage or in small sips during meals to aid digestion. warnings Do not use during pregnancy, breastfeeding, preoperatively, in case of peptic ulcer or hepatitis; may increase the absorption and half-life of antiplatelet drugs, tetracyclines and hypoglycemics. Conservation Store at room temperature. Shelf life in intact packaging: 36 months. Format 200 ml bottle. Code 180925 Bibliography Barun KB Bromelain: an overview. Nat. Prod. Rad. 7(4):359-363. 2008. Maurer HR Bromelain: biochemistry, pharmacology and medical use. Cell Mol. Life Sci. 58(9):1234-45. 2001. Nguyen NH. et al. “Antioxidant effects of superoxide dismutase 3 on inflammatory diseases”. J. Mol. Med. (Berl). doi: 10.1007/s00109-019-01845-2. 2019. Ordesi P. et al. “Therapeutic efficacy of bromelain in impacted third molar surgery: a randomized controlled clinical trial.” Quintessence Int. 45(8):679-84. 2014. Rathnavelu V et al. “Potential role of bromelain in clinical and therapeutic applications”. Biomed Rep. 5(3):283-288. 2016. Vouldoukis I. et al. Antioxidant and anti-inflammatory properties of a Cucumis melo LC. extract rich in superoxide dismutase activity. J. Ethnopharmacol. 94(1):67-75. 2004