The balanced combination of natural products that contribute to the proper functioning of the prostate and urinary system. BENEFITS Various herbal extracts obtained from the roots, seeds, fruits or bark of various plants, such as Saw palmetto (Serenoa Repens) contain numerous active ingredients that contribute to the proper functioning of the prostate and urinary system, such as phytosterols , β-sitosterol , quercetin , lycopene, terpenoids, fatty acids, lectins, vegetable oils, polysaccharides, flavonoids, phytoestrogens and sterols. The D-PROSTA food supplement is a combination of phytotherapeutic factors, Saw palmetto (Serenoa Repens), quercetin and lycopene, and non-pharmaceutical factors, zinc and vitamin D, in an adequate concentration, to support the normal functioning of the prostate and lower urinary system with a single daily dose . It has anti-inflammatory , decongestant action and helps to relieve symptoms caused by chronic and acute benign prostatic hyperplasia, without affecting sexual ability. ingredients Saw palmetto ( Serenoa Repens ) Saw palmetto is a small, perennial palm that grows on the southern coasts of the United States and in tropical Central and South America. Its fruit is black and oval or spherical, rich in fatty acids and phytosterols. Based on a wealth of certified scientific data, it has been classified as a key phytotherapeutic for the symptomatic treatment of prostate and lower urinary tract problems. Proposed mechanisms of action include: Antiandrogenic action Inhibition of 5-alpha-reductase type 1 and 2 isoenzymes Inhibition of growth factors Anti-inflammatory action Antiestrogenic action Antiproliferative action. Quercetin A flavonoid found in over 20 fruits and vegetables, known for its anti-inflammatory, antioxidant and anticancer properties. It exhibits antihypertensive, vasodilatory properties, as well as action against obesity, hypercholesterolemia and atherosclerosis. It is noteworthy that, despite its potent cytotoxic action on cancer cells, it exhibits little or no toxicity on normal cells. In addition, it induces apoptosis while inhibiting cell proliferation through various mechanisms (Table 1). Its therapeutic effect has been studied in many forms of cancer, both in vitro and in vivo, with a wealth of data relating to prostate cancer. Quercetin appears to inhibit the initiation of this type of cancer by indirectly inhibiting two very important genes, AR and PSA. In vivo studies on the administration of a combination of quercetin and chemotherapy have shown reversal of resistance in cancer cells, as well as limiting the side effects of chemotherapy. Clinical trials are needed to determine the necessary dose and duration of administration, as well as to identify biomarkers that predict response to treatment. Finally, the clinical use of quercetin has not yet been established due to limited data on its pharmacokinetics.LYCOPENE Lycopene is an antioxidant that belongs to the carotenoid family and is found in red and yellow fruits and vegetables. It has antioxidant and antiproliferative properties and exhibits anticancer activity through its involvement in the activation and induction of apoptosis, cell cycle arrest and mechanisms of cell adhesion, metastasis, invasion and angiogenesis. It also reduces serum PSA levels and controls inflammatory cytokines. These findings suggest that lycopene could be used in the prevention and even treatment of prostate cancer. In men at high risk of developing prostate cancer, increasing dietary intake of lycopene may lead to changes in circulating levels of valine, oxalic acid, pyrostafelic acid and diacetylglycerol. Based on studies, lycopene may be causally linked to prostate cancer. Therefore, lycopene, by reducing its levels, may help prevent prostate cancer in these individuals.Zinc (sulfate) Prostatic fluid and the peripheral zone of the prostate are known to contain high levels of zinc (Zn) and citrate. Specifically, the concentration of Zn in prostatic fluid is estimated to be 590 µg/g, which is approximately 500 times higher than in plasma, while in the peripheral zone it is 10-20 times higher than in other similar structures in the body. This is because the epithelial cells of the peripheral zone accumulate Zn required for citrate production and secretion in the prostate, leading to inhibition of mitochondrial aconitase, which catalyzes the conversion of citrate to isocitrate in the early stages of the Krebs cycle. Therefore, high Zn concentrations lead to high citrate concentrations and a high citrate/isocitrate ratio in the epithelial cells of the peripheral zone of the prostate, indicating a very important role of Zn in the normal prostate. Decreased Zn levels (60-80%), and thus citrate, are the most characteristic feature of prostate cancer and are inversely proportional to disease progression. The role of Zn as a regulator of apoptosis makes it possible that this decrease is a causal factor and not a consequence of the disease. Therefore, adequate dietary intake of Zn is very important for adult men, as it improves normal prostate function and prevents age-related diseases.Cholecalciferol (Vitamin D3) Cholecalciferol is a molecular form of vitamin D and is produced in the skin under the influence of sunlight. It is fat-soluble and is involved in the absorption of calcium and phosphorus, participating in bone metabolism, while also playing an important role in other tissues. Signaling through the cholecalciferol receptor appears to be important in prostate cancer. Administration of cholecalciferol to tumor models in mice inhibited tumor growth. In summary, it has been found to be involved in the induction of cell cycle arrest, apoptosis, expression of the p53 tumor suppressor gene, differentiation and inhibition of angiogenesis, invasion and metastasis. However, the exact mechanism of its anticancer action has not yet been determined.